Prostate Cancer Chemoprevention By A Flavonoid Supplemented Diet In The Transgenic Adenonocarcinoma Of The Murine Prostate ( TRAMP ) Model |
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Prostate Cancer Chemoprevention By A Flavonoid Supplemented Diet In The Transgenic Adenonocarcinoma Of The Murine Prostate ( TRAMP ) ModelORLANDO, FL ( UroToday. com ) - Dietary and environmental factors have been postulated to account for differences in prostate cancer incidence and mortality worldwide. Amongst many dietary components implicated in apparent chemopreventive effect of the components implicated in apparent chemopreventive effect of Asian diet is group of micronutrients called flavonoids, consumed in high amounts in these regions. In previous screening experiments, this group of Canadian researchers identified 4 flavonoids ( 2, 2'-dihydroxychalcone [DHC], fisetin, quercetin and luteolin ) with anti-proliferative effects in prostate cancer cell lines. The researchers hypothesized that oral consumption of these flavonoids reduces the incidence and progression of prostate cancer in a transgenic animal model. They used Transgenic Adenocarcinoma of the Murine Prostate ( TRAMP ) model. Mice ( 20 per group ) were fed one of 4 diets ad libitum for 28 weeks from weaning: 1 ) Flavonoid free control, 2 ) 1% fisetin, 3 ) 1%DHC, and 4 ) 1% combination flavonoid diet. Mice underwent weekly body weight measurements and were monitored for signs of toxicity. At 32 weeks of age, mice were sacrificed and serum and tissue collected for further analysis. There was a 63% reduction in wet prostate tumor weight in the combination flavonoid group compared to control ( mean 2. 2g vs 5. 8g, p=0. 0033 ) . In addition, we observed a 44% reduction in the number of mice with histologic evidence of prostate cancer in combination flavonoid group compared to flavonoid-free control, with non-significant reductions noted for fisetin and DHC alone groups. There was no evidence of toxicity based on body weight measurements, histological examination of major organs and hematological parameters. Analysis of flavonoid levels by liquid chromatography/mass spectrometry confirmed target site availability of unaltered flavonoid in prostate tissue. They conclude that a combination flavonoid died can inhibit progression of prostate carcinogenesis in a transgenic model. Presented by Ahmed Haddad, MD, Vasundara Venkateswaran, MD, Neil E Fleshner, MD, Linda M Sugar, MD, Emma Guns, MD, and Laurence H Klotz, MD, at Annual Meeting of American Urological Association ( AUA ) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA. Reported by UroToday. com Contributing Editor Christopher P. Evans, MD, FACS UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday , go to: www. urotoday. com Copyright 2008 - UroToday Keep in touch. Latest healthcare tips from professionals. |
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Prostate Cancer Chemoprevention By A Flavonoid Supplemented Diet In The Transgenic Adenonocarcinoma Of The Murine Prostate ( TRAMP ) Model The medicine that help us: Metoprolol. Delivery options for Metoprolol OTC Cough and Cold Products: Not For Infants and Children Under 2 Years of Age, Questions and Answers for Consumers. FDA strongly recommends that over-the-counter (OTC) cough and cold products should not be used in infants and children under 2 years of age. Keep in touch. Latest healthcare tips from professionals. |